Hydroxypropyl Methylcellulose (HPMC) ni polymer itandukanye ikoreshwa cyane mu nganda zitandukanye, harimo imiti, ibiryo, amavuta yo kwisiga, nubwubatsi.Imiterere yihariye ituma iba umukandida mwiza mubisabwa nko gusohora ibiyobyabwenge bigenzurwa, kubyimba ibintu, gutwika firime, nibikoresho byubwubatsi.Muri iyi ngingo, tuzacengera muburyo bwo gusesa HPMC, dusuzume akamaro kayo, tekinike, nibisabwa.Gusobanukirwa uburyo bwo gusesa HPMC ningirakamaro mugutezimbere imikorere yayo no kugera kubisubizo byifuzwa mubice bitandukanye.
Akamaro ko gusesa HPMC
Iseswa rya HPMC bivuga inzira yo gukwirakwiza no gushonga polymer muburyo bwamazi.Iyi ntambwe irakomeye kuko igena igipimo cyo gusohora, bioavailability, hamwe nibikorwa byibicuruzwa bishingiye kuri HPMC.Imyitwarire yo gusesa ya HPMC biterwa nibintu bitandukanye, harimo urwego rwa HPMC, ingano yingingo, ubushyuhe, pH, na miterere yikigereranyo.Mu kwiga uburyo bwo gusesa, abashakashatsi nababikora barashobora gusuzuma ibishobora gukemuka, kurekura kinetics, hamwe nibikorwa rusange byimikorere ya HPMC, biganisha kumajyambere yibicuruzwa no gutezimbere.
Ubuhanga bwo gusesa HPMC
Tekinike nyinshi zikoreshwa mukwiga imyitwarire yo gusesa HPMC.Uburyo bukoreshwa cyane harimo:
a.Igikoresho cya I (Igikoresho cya Basket): Ubu buryo bukubiyemo gushyira icyitegererezo cya HPMC mu gatebo gashya, hanyuma kinjizwa mu buryo bwo gusesa mugihe gikanguwe.Ubu buhanga bukoreshwa kenshi muburyo bwo gusohora ako kanya kandi butanga amakuru yingirakamaro ku gipimo cyo gusesa no gusohora umwirondoro wa HPMC.
b.Igikoresho cya II (Paddle apparatus): Muri ubu buryo, icyitegererezo gishyirwa mu cyombo gisenyuka, kandi padi ikoreshwa muguhagarika imiyoboro.Ubu buhanga burakwiriye kurekurwa byihuse no kwagurwa-kurekura, gutanga ubushishozi ku gipimo cyo gusesa no kurekura kinetics ya HPMC.
c.Igikoresho cya III (Isubiranamo rya silindari): Ubu buhanga bukubiyemo gushyira icyitegererezo muri silindiri isubiranamo, igenda isubira inyuma muburyo bwo gusesa.Ubu buryo bukoreshwa muburyo bwo kwiga HPMC ishingiye ku kwagura-gusohora kandi itanga amakuru ku gipimo cyo kurekura n’imyitwarire yo gukwirakwiza ibiyobyabwenge.
d.Igikoresho cya IV (Flow-through selire apparatus): Ubu buryo bukoreshwa cyane cyane mukwiga HPMC ishingiye kuri transdermal patch cyangwa membrane.Icyitegererezo gishyizwe hagati y'ibice bibiri, kandi uburyo bwo gusesa bwemerewe kunyura muri sample, bigereranya irekurwa ry'ibiyobyabwenge hirya no hino.
Gukoresha uburyo bwa HPMC bwo gusesa
Uburyo bwo gusesa HPMC isanga ibikorwa byinshi mubikorwa bitandukanye:
a.Inganda zimiti: HPMC ikoreshwa cyane nka matrix polymer kugirango igenzurwe nibiyobyabwenge.Uburyo bwo gusesa bufasha kumenya igipimo cyo kurekura, imyitwarire yo gukwirakwiza ibiyobyabwenge, hamwe nuburyo bwo kurekura ibinini bishingiye kuri HPMC, capsules, na pellet.Aya makuru ningirakamaro mugutezimbere itangwa ryibiyobyabwenge no kwemeza ibisubizo bivura kandi byateganijwe.
b.Inganda zibiribwa: HPMC ikoreshwa nkibintu byiyongera kandi bigahindura ibicuruzwa byibiribwa nka sosi, imyambarire, n'ibinyobwa.Uburyo bwo gusesa bufasha mu gusobanukirwa ibiranga hydrata na solubilité biranga HPMC mu mibare itandukanye y'ibiryo, bigira uruhare mu kunoza imiterere, ituze, hamwe n'ibiranga ibicuruzwa byanyuma.
c.Inganda zo kwisiga: HPMC ikoreshwa mubintu byo kwisiga no kwita kubantu kugiti cyabo nkumukozi ukora firime, stabilisateur ya emulsiyo, hamwe na modifier ya viscosity.Uburyo bwo gusesa bufasha gusuzuma imiterere ya firime na firime ya HPMC, kwemeza ibicuruzwa byifuzwa, gukwirakwizwa, hamwe nubuzima bwiza.
